Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
tert-Butanol → tert-butyl N-(5-bromo-2-chlorophenyl)carbamate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | tert-Butanol | HCID 6386 | — |
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | 5-Bromo-2-chlorobenzoic acid | HCID 33127 | — |
| 반응물 | P,P-Diphenylphosphinic azide | HCID 199401 | — |
| 생성물 | tert-butyl N-(5-bromo-2-chlorophenyl)carbamate | HCID 57840526 | — |
반응 단계
A solution of 5-Bromo-2-Chloro benzoic acid (24 g, 0.1 mol), di-phenylphosphoryl azide (28 mL, 1.3 eq), and Et3N (140 mL, 10 eq) in tert-butanol (300 mL) was refluxed for 3 hrs. The resulting solution was concentrated under reduced pressure, diluted with ether (300 mL) and washed with HCl 1N (300 mL), saturated solution of NaHCO3 (200 mL), and brine (200 mL). The organic layers was dried over anhydrous sodium sulfate and concentrated. Chromatography on silica (EtOAc/n-hexane) yielded, (26 g, 85%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08044041B2 |
| 출처 데이터셋 | uspto-grants-2011_10 |
| ORD ID | ord-5f414bda7e1746bea9e738391638c0ce |
| 출처 메모 | uspto-grants-2011_10 |