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Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 1668913생성일: 2026년 10월 24일

6-Methyl-5-nitro-N-(3-(trifluoromethyl)phenyl)isoquinolin-l-amine → 6-methyl-N1-(3-(trifluoromethyl)phenyl)isoquinoline-1,5-diamine

https://huagongshe.com/ko/reaction/1668913

반응식

참여 물질

역할이름HCID투입량
반응물6-Methyl-5-nitro-N-(3-(trifluoromethyl)phenyl)isoquinolin-l-amineHCID 67339476—
촉매PalladiumHCID 23938—
용매EthanolHCID 702—
생성물6-methyl-N1-(3-(trifluoromethyl)phenyl)isoquinoline-1,5-diamineHCID 44478903—

반응 단계

6-Methyl-5-nitro-N-(3-(trifluoromethyl)phenyl)isoquinolin-1-amine (0.28 g, 0.81 mmol) was dissolved in ethanol (20 mL) and 10% palladium on carbon (0.086 g, 0.81 mmol) was added to the solution. The reaction stirred overnight at RT under a hydrogen atmosphere. The reaction was filtered through celite and concentrated to give the title compound as a pink film (0.25 g, 98%). MS (M+H)+ 318.

출처 및 근거

DOI10.6084/m9.figshare.5104873.v1
특허 번호US07989461B2
출처 데이터셋uspto-grants-2011_08
ORD IDord-dcef76f14a72408db9f612a2eb14bbea
출처 메모uspto-grants-2011_08