Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Tetrabutylammonium Fluoride → 1-(1,4-dioxa-spiro[4.5]dec-8-yl)-1H-[1,2,3]triazole
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Tetrabutylammonium Fluoride | HCID 2724141 | — |
| 반응물 | 1-(1,4-dioxa-spiro[4.5]dec-8-yl)-4-trimethylsilanyl-1H-[1,2,3]triazole | HCID 57795425 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 용매 | Ethyl Acetate | HCID 8857 | — |
| 생성물 | 1-(1,4-dioxa-spiro[4.5]dec-8-yl)-1H-[1,2,3]triazole | HCID 57424095 | — |
반응 단계
A solution of 1-(1,4-dioxa-spiro[4.5]dec-8-yl)-4-trimethylsilanyl-1H-[1,2,3]-triazole (1.60 g, 5.68) in 41 mL of dry THF is treated by a 1M solution of tetrabutylammonium fluoride in THF (9.0 mL, 9.0 mmol). The resulting mixture is stirred for 48 h at room temperature under nitrogen. It is diluted with EtOAc, washed with saturated aqueous ammonium chloride, water and brine, dried over Na2SO4 and concentrated to give 1-(1,4-dioxa-spiro[4.5]dec-8-yl)-1H-[1,2,3]triazole.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08003685B2 |
| 출처 데이터셋 | uspto-grants-2011_08 |
| ORD ID | ord-403c3b9670c242a5b7ab93335899bdd7 |
| 출처 메모 | uspto-grants-2011_08 |