Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
(R)-1-Phenylpropylamine → (R)-1-(benzyloxycarbonylamino)-2-methylpropylphosphonous acid
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | (R)-1-Phenylpropylamine | HCID 5324978 | — |
| 반응물 | 1-Carbobenzyloxyamino-2-methylpropanephosphonous acid | HCID 21325852 | — |
| 용매 | Ethanol | HCID 702 | — |
| 용매 | Ethyl Acetate | HCID 8857 | — |
| 생성물 | (R)-1-(benzyloxycarbonylamino)-2-methylpropylphosphonous acid | HCID 67375324 | 32.4% |
반응 단계
A solution of 1-(benzyloxycarbonylamino)-2-methylpropylphosphonous acid (3.4 g, 12.5 mmol) in 20 mL of absolute ethanol was heated to reflux and (R)-(+)-methylbenzylamine (96% ee, 1.5 g, 12.5 mmol) was added. The resulting mixture was diluted with 120 mL of ethyl acetate. The precipitate was filtered off, washed with 100 mL of ethyl acetate and 100 mL of ether, dried in vacuo to afford (R)-1-(benzyloxycarbonylamino)-2-methylpropylphosphonous acid as a white solid (1.1 g) with a rotation [α]D=−10.87° (c=10 mg/mL 9:1 DMF-H2O). This material was found to be 93% ee by chiral HPLC.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08008325B2 |
| 출처 데이터셋 | uspto-grants-2011_08 |
| ORD ID | ord-6ea9d939b9b74e04a2d660d2ee438185 |
| 출처 메모 | uspto-grants-2011_08 |