Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Dichloromethane → 2-cyano-N-(1,1-dimethylethyl)-2-(hydroxyimino)acetamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Dichloromethane | HCID 6344 | — |
| 반응물 | Nitrosyl chloride | HCID 17601 | — |
| 반응물 | N-tert-butyl-2-cyanoacetamide | HCID 1515876 | — |
| 용매 | Chloroform | HCID 6212 | — |
| 생성물 | 2-cyano-N-(1,1-dimethylethyl)-2-(hydroxyimino)acetamide | HCID 72973983 | — |
반응 단계
2-Cyano-N—(1,1-dimethylethyl)acetamide 11 (Bhawal, B. M.; Khanapure, S. P.; Biehl, E. R.; Syn. Commun., 1990, 20, 3235) is allowed to react with nitrosyl chloride in an inert organic solvent such as CH2Cl2 or CHCl3 at moderate temperature (e.g., ambient temperature to −25° C., preferably about 0° C.). The resulting 2-cyano-N-(1,1-dimethylethyl)-2-(hydroxyimino)acetamide 13 is isolated and reduced, for example with sodium dithionite in an aqueous organic solvent, but preferably with aluminum amalgam in water at moderate temperature (e.g., ambient temperature to about 0° C., preferably about 0° C.).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07737284B2 |
| 출처 데이터셋 | uspto-grants-2010_06 |
| ORD ID | ord-943501e6c888465ebf94f27ad6f38802 |
| 출처 메모 | uspto-grants-2010_06 |