Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 17271생성일: 2026년 10월 24일
Dimethylformamide → N-(3-bromo-6-cyano-2-methoxy-5-methyl-4-styrylphenyl)-2,2-dimethylpropionamide
https://huagongshe.com/ko/reaction/17271
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Dimethylformamide | HCID 6228 | — |
| 반응물 | Styrylboronic acid | HCID 5702628 | — |
| 반응물 | N-(3-Bromo-6-cyano-4-iodo-2-methoxy-5-methylphenyl)-2,2-dimethylpropionamide | HCID 86630795 | — |
| 촉매 | HCID 178418397 | HCID 178418397 | — |
| 용매 | Ethyl Acetate | HCID 8857 | — |
| 생성물 | N-(3-bromo-6-cyano-2-methoxy-5-methyl-4-styrylphenyl)-2,2-dimethylpropionamide | HCID 86630802 | — |
반응 단계
Tetrakis(triphenylphosphine)palladium(0) (6.4 mg, 5.5 μmol) was added to an N,N-dimethylformamide (1.0 ml) suspension of N-(3-bromo-6-cyano-4-iodo-2-methoxy-5-methylphenyl)-2,2-dimethylpropionamide (I-6) (50 mg, 111 μmol), trans-β-styreneboronic acid (17.2 mg, 116 μmol), potassium phosphate n-hydrate (74-78%, 64 mg, 222 μmol), followed by stirred overnight at 95° C. The reaction liquid was cooled, then ethyl acetate (30 ml) was added, followed by washing with saturated brine (30 ml×2), drying over anhydrous magnesium sulfate, concentrating under reduced pressure.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US07737166B2 |
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| 출처 데이터셋 | uspto-grants-2010_06 |
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| ORD ID | ord-be1549dc55c14a9f9e3975d546dc35d8 |
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| 출처 메모 | uspto-grants-2010_06 |
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