Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Dichloromethane → 3-Aminopyrazine-2-carboxylic acid 2-chlorophenylamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Dichloromethane | HCID 6344 | — |
| 반응물 | 2-Chloroaniline | HCID 7240 | — |
| 반응물 | 3-Amino-2-pyrazinecarboxylic acid | HCID 72656 | — |
| 반응물 | 1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride | HCID 2723939 | — |
| 촉매 | 4-(Dimethylamino)pyridine | HCID 14284 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | 3-Aminopyrazine-2-carboxylic acid 2-chlorophenylamide | HCID 54096972 | 50% |
반응 단계
A mixture of 3-aminopyrazine carboxylic acid (7.0 g, 50.32 mmol), methylene chloride (60 mL), dimethylformamide (40 mL), 4-dimethylaminopyridine (15.37 g, 126 mmol), 2-chloroaniline (5.82 mL, 55.35 mmol), and 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (11.58 g, 60.38 mmol) was stirred overnight at ambient temperature. The solvent was removed and the residue was mixed with ethyl acetate and 1 N lithium chloride. The precipitate which formed was filtered and rinsed with 1 N lithium chloride, ethyl acetate, and ether and then air dried to afford 6.22 g (50%) of 3-aminopyrazine-2-carboxylic acid 2-chlorophenylamide as fluffy yellow crystals.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05962457 |
| 출처 데이터셋 | uspto-grants-1999_10 |
| ORD ID | ord-a675d8e5dc164ae1863f90a786c27a9a |
| 출처 메모 | uspto-grants-1999_10 |