Ethyl 1-(6-chloronaphth-2-ylsulphonyl)piperazine-3-carboxylate → HCID 22721818, 화합물

HRID 1738870

반응식

HRID 1738870 반응식
[N:1]1[CH:6]=[CH:5][C:4]([N:7]2[CH2:12][CH2:11][CH:10]([C:13](Cl)=[O:14])[CH2:9][CH2:8]2)=[CH:3][CH:2]=1.[Cl:16][C:17]1[CH:18]=[C:19]2[C:24](=[CH:25][CH:26]=1)[CH:23]=[C:22]([S:27]([N:30]1[CH2:35][CH2:34][NH:33][CH:32]([C:36]([O:38][CH2:39][CH3:40])=[O:37])[CH2:31]1)(=[O:29])=[O:28])[CH:21]=[CH:20]2>>[Cl:16][C:17]1[CH:18]=[C:19]2[C:24](=[CH:25][CH:26]=1)[CH:23]=[C:22]([S:27]([N:30]1[CH2:35][CH2:34][N:33]([C:13]([CH:10]3[CH2:11][CH2:12][N:7]([C:4]4[CH:5]=[CH:6][N:1]=[CH:2][CH:3]=4)[CH2:8][CH2:9]3)=[O:14])[CH:32]([C:36]([O:38][CH2:39][CH3:40])=[O:37])[CH2:31]1)(=[O:28])=[O:29])[CH:21]=[CH:20]2

참가 물질

3

반응물 2

HCID 10970999Ethyl 1-(6-chloronaphth-2-ylsulphonyl)piperazine-3-carboxylateHCID 111837001-(4-Pyridinyl)-4-piperidinecarbonyl chloride

생성물 1

HCID 22721818HCID 22721818, 화합물수율 37%

실험 절차

Using an analogous procedure to that described in Example 1, 1-(4-pyridyl)piperidine-4-carbonyl chloride was reacted with ethyl 1-(6-chloronaphth-2-ylsulphonyl)piperazine-3-carboxylate to give 4-(6-chloronaphth-2-ylsulphonyl)-2-ethoxycarbonyl-1-[1-(4-pyridyl)-piperidin-4-ylcarbonyl]piperazine in 37% yield;

출처 및 근거

ORD 기록
ord-f962760a25534aff9843337c1eb98f1f
출처 데이터셋
uspto-grants-1999_10
특허 번호
US05965559

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