1,4-Dioxane → 6-Chloroquinoline-2-carbaldehyde

HRID 1754185

반응식

[Cl:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[C:7]([CH3:12])[CH:6]=[CH:5]2.[O:13]1CCOCC1>>[Cl:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[C:7]([CH:12]=[O:13])[CH:6]=[CH:5]2

참가 물질

반응물 2

HCID 312751,4-Dioxane

HCID 1359656-Chloroquinaldine

생성물 1

HCID 2712836-Chloroquinoline-2-carbaldehyde

반응 조건

온도: 80 °C

실험 절차

A suspension of 6-chloro-2-methyl-quinoline (355 mg) and SeO2 (233 mg) in 1,4-dioxane (3 mL) was heated at 80° C. for 16 h. The resulting black mixture was filtered through diatomaceous earth. Concentration of the filtrate gave the title compound as a yellow powder (324 mg).

후처리

filtrationThe resulting black mixture was filtered through diatomaceous earth

출처 및 근거

ORD 기록: ord-702b5cb735f344b49494112650992b01
출처 데이터셋: uspto-grants-2015_10
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US09169224B2

연결된 노트

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