Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Methanol → 2-Chloro-8-fluoroindolo[2,1-b]quinazoline-6,12-dione
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Methanol | HCID 887 | — |
| 반응물 | Sodium hydride | HCID 24758 | — |
| 반응물 | 5-Chloroisatoic anhydride | HCID 78480 | — |
| 반응물 | 5-Fluoroisatin | HCID 236566 | — |
| 용매 | Chloroform | HCID 6212 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | 2-Chloro-8-fluoroindolo[2,1-b]quinazoline-6,12-dione | HCID 478569 | — |
반응 단계
To a suspension of NaH (10 mmol, 40 mg 60%) in 4 mL of DMF was added 10 mmol of 5-fluoroisatin in 2 mL of DMF. After 15 min, a solution of 5-chloroisatoic anhydride in 3 mL of DMF was added. The reaction mixture was stirred for 18 h, methanol (0.5 mL) and 20 mL of chloroform was added and the organic solution was washed with water, dried (MgSO4) and concentrated to give a residue which was purified by silica gel chromatography (CHCl3 :CH3OH). Yield 77%: mp 280°-282° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05441955 |
| 출처 데이터셋 | uspto-grants-1995_08 |
| ORD ID | ord-0cfebdd3820a4315bfe8dcf209410365 |
| 출처 메모 | uspto-grants-1995_08 |