Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Nitric Acid → 6-fluoro-5-nitro-2(3H)-benzothiazolone
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Nitric Acid | HCID 944 | — |
| 반응물 | Sulfuric Acid | HCID 1118 | — |
| 반응물 | 2-Benzothiazolinone, 6-fluoro- | HCID 44667 | — |
| 생성물 | 6-fluoro-5-nitro-2(3H)-benzothiazolone | HCID 13957955 | — |
반응 단계
Explaining the above conversion, 6-fluoro-2(3H)-benzothiazolone (V) [G. Mazzone et al: Farmaco, Ed. Sc., 32, (5), 348 (1977)] is reacted with a nitrating agent such as a mixture of sulfuric acid and nitric acid to give 6-fluoro-5-nitro-2(3H)-benzothiazolone (VI). The reaction is accomplished at a temperature of -10° to 10° C. instantaneously or within 5 hours. Sulfuric acid and nitric acid are respectively used in amounts of one equivalent to an excess amount and of 1 to 1.2 equivalents to the compound (V).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04828605 |
| 출처 데이터셋 | uspto-grants-1989_05 |
| ORD ID | ord-15bfc09a43274776a545a16ec9209664 |
| 출처 메모 | uspto-grants-1989_05 |