Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2-Methylimidazole → Estazolam
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2-Methylimidazole | HCID 12749 | — |
| 반응물 | Methanimidamide, hydrochloride (1:1) | HCID 10313058 | — |
| 반응물 | 7-Chloro-2-hydrazinyl-5-phenyl-3H-1,4-benzodiazepine | HCID 12390874 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | Estazolam | HCID 3261 | — |
반응 단계
A mixture of 2.8 parts of 7-chloro-2-hydrazino-5-phenyl-3H-1,4-benzodiazepine, 2.4 parts of formamidine hydrochloride and 2.5 parts of 2-methylimidazole is fused at 160° C for 10 minutes. Water is added to the mixture, followed by extraction with methylene chloride. The methylene chloride layer is washed with water, dried over sodium sulfate and the solvent is evaporated, whereby 8-chloro-6-phenyl-4H-s-triazolo [4,3-a][1,4] benzodiazepine is yielded. Recrystallization from ethyl acetate yields colorless flakes melting at 226° C to 227° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04116956 |
| 출처 데이터셋 | uspto-grants-1978_09 |
| ORD ID | ord-2f9d688256f6492a8e3493b7ddfa1c2a |
| 출처 메모 | uspto-grants-1978_09 |