Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Ammonia → 1-[2-(4-Chlorophenyl)ethyl]piperazine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Ammonia | HCID 222 | — |
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | L-Cysteinylglycine | HCID 439498 | — |
| 반응물 | 1-{4-[N-(2-isopropyloxyethyl)-N-chloroacetylamino]benzoyl}-4-[2-(4-chlorophenyl)ethyl]piperazine | HCID 9807391 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | 1-[2-(4-Chlorophenyl)ethyl]piperazine | HCID 12235714 | — |
반응 단계
Analogously to Example 1, 1.6 g of 1-{4-[N-(2-isopropoxyethyl)-N-chloroacetyl-amino]-benzoyl}-4-[2-(4-chlorophenyl)-ethyl]-piperazine--freed from the corresponding hydrochloride by treatment with a mixture of aqueous ammonia solution/methylene chloride--are reacted with 0.55 g of L-cysteinyl-glycine, yielding 1-{{4-{N-2-isopropoxyethyl)-N-[[[2R]-2-[N'-(carboxymethyl)carbamoyl]-2-amino-ethylmercapto-acetyl]]-amino}-benzoyl}}-4-[2-(4-chlorophenyl)-ethyl]-piperazine. The hemihydrate thereof has a melting point of 85°-87° and an αD25 =-1.5° (c=0.545%, methanol).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05380726 |
| 출처 데이터셋 | uspto-grants-1995_01 |
| ORD ID | ord-7502e364967e4e01878d20fed8cab89f |
| 출처 메모 | uspto-grants-1995_01 |