Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Bromine → 1-Benzyluracil
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Bromine | HCID 24408 | — |
| 반응물 | 1-Benzyl-5-bromo-1,2,3,4-tetrahydropyrimidine-2,4-dione | HCID 5276659 | — |
| 용매 | Dimethyl Sulfoxide | HCID 679 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | 1-Benzyluracil | HCID 237962 | — |
반응 단계
This experiment was performed to verify the role of DMSO solvent in the generation of the bromine electrophile. Thus, this synthesis was done following the same procedure as for the synthesis of 1-benzyl-5-bromouracil, with the sole exception that DMSO was replaced by dimethylformamide (DMF), as solvent. Extraction was done by water-EtOAc and crystallization was done from EtOAc-Hexanes. After filtration, washing with hexanes and drying under high vacuum, 1.4 g of pure 1-benzyluracil, was isolated, as clean white crystals with properties shown below.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07501429B2 |
| 출처 데이터셋 | uspto-grants-2009_03 |
| ORD ID | ord-2279370aa0c2485cbfa231929bf5bf2b |
| 출처 메모 | uspto-grants-2009_03 |