Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Acetic Anhydride → (4-Bromopyridin-2-yl)methyl acetate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Acetic Anhydride | HCID 7918 | — |
| 반응물 | 4-Bromo-2-methyl-1-oxo-1lambda~5~-pyridine | HCID 54446139 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | (4-Bromopyridin-2-yl)methyl acetate | HCID 45789873 | — |
반응 단계
To a solution of 4-bromo-2-methylpyridine-1-oxide (4.00 g, 21.40 mmol) in DCM (20 mL) is added acetic anhydride (6 mL). The mixture is stirred at room temperature for 1 hour and then heated at reflux overnight. The solvent is removed under vacuum and the crude product is filtered through a silica plug, eluting with DCM to afford the title compound as an orange oil (815 mg).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07501411B2 |
| 출처 데이터셋 | uspto-grants-2009_03 |
| ORD ID | ord-0c44e6b863894bd3bbec0160a1725659 |
| 출처 메모 | uspto-grants-2009_03 |