Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 1785239생성일: 2026년 10월 24일
Cesium carbonate → 3-{2-Methyl-4-[5-(4-trifluoromethyl-phenyl)-thiophen-2-ylmethoxy]-phenyl}-propionic acid methyl ester
https://huagongshe.com/ko/reaction/1785239
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Cesium carbonate | HCID 10796 | — |
| 반응물 | Methyl 3-(4-Hydroxy-2-methylphenyl)propanoate | HCID 13551833 | — |
| 반응물 | 2-(Chloromethyl)-5-(4-(trifluoromethyl)phenyl)thiophene | HCID 57594979 | — |
| 용매 | Acetonitrile | HCID 6342 | — |
| 생성물 | 3-{2-Methyl-4-[5-(4-trifluoromethyl-phenyl)-thiophen-2-ylmethoxy]-phenyl}-propionic acid methyl ester | HCID 68853010 | — |
반응 단계
To a solution of 2-Chloromethyl-5-(4-trifluoromethyl-phenyl)-thiophene (0.210 g, 0.760 mmole) and 3-(4-Hydroxy-2-methyl-phenyl)-propionic acid methyl ester (0.147 g, 0.760 mmole) in acetonitrile (5 mL), is added cesium carbonate (0.248 mL, 0.760 mmole) in one portion. The reaction is heated at 50° C. overnight, then concentrated. The residue is loaded to a silica gel column, eluted with ethyl acetate in hexane (0-15%) and concentrated to provide the titled compound as a white solid.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US07504433B2 |
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| 출처 데이터셋 | uspto-grants-2009_03 |
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| ORD ID | ord-1a0af10095864711a1b8cd8e75ad68c5 |
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| 출처 메모 | uspto-grants-2009_03 |
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