Nitric Acid → 5-Bromo-3-nitro-2-pyridone

HRID 1817906

반응식

HRID 1817906 반응식
[Br:1][C:2]1[CH:3]=[CH:4][C:5](=[O:8])[NH:6][CH:7]=1.[N+:9]([O-])([OH:11])=[O:10]>S(=O)(=O)(O)O>[Br:1][C:2]1[CH:3]=[C:4]([N+:9]([O-:11])=[O:10])[C:5](=[O:8])[NH:6][CH:7]=1

참가 물질

4

반응물 2

HCID 944Nitric AcidHCID 5995285-Bromo-2-hydroxypyridine

생성물 1

HCID 851475-Bromo-3-nitro-2-pyridone수율 68%

시약·촉매·용매 1

HCID 1118Sulfuric Acid용매

실험 절차

To a solution of 5-bromopyridin-2(1H)-one (Aldrich, 3.0 g, 17.2 mmol) in sulfuric acid (18 mL) was added nitric acid (60-61%, Wako Pure Chemical Industries, Ltd., 6 mL) at 0° C. The mixture was allowed to warm to room temperature and stirred for 3 h. The mixture was poured into ice water and obtained precipitate was collected by filtration. The solid was washed with water and dried in vacuo to afford the title compound (2.5 g, 68%) as a yellow solid.

후처리

  1. customobtained precipitate
  2. filtrationwas collected by filtration
  3. washThe solid was washed with water
  4. customdried in vacuo

출처 및 근거

ORD 기록
ord-5f67e26f086f409cb172e3afd6e785a8
출처 데이터셋
uspto-grants-2009_10
특허 번호
US07598393B2

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