참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Diethyl Ether | HCID 3283 | — |
| 반응물 | Tetrafluoroboric acid | HCID 28118 | — |
| 반응물 | N-(5-Amino-4-methylpyridin-2-yl)acetamide | HCID 22063573 | — |
| 반응물 | Sodium Nitrite | HCID 23668193 | — |
| 생성물 | 6-(Acetylamino)-4-methyl-3-pyridinediazonium tetrafluoroborate | HCID 22063668 | — |
반응 단계
The N1-(5-amino-4-methyl-2-pyridyl)acetamide (8.00 g, 48.4 mmol) obtained in (B) was dissolved in tetrafluoroboric acid (160 ml) and slowly added dropwise with an aqueous solution (40 ml) of sodium nitrite (3.51 g, 50.8 mmol) at −20° C. under nitrogen atmosphere. The reaction mixture was further stirred at −10° C. for 1 hour and added with diethyl ether (800 ml), and the deposited white solid was collected by filtration and washed with diethyl ether to obtain the title compound (14.7 g, quantitative).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US07056917B2 |
|---|
| 출처 데이터셋 | uspto-grants-2006_06 |
|---|
| ORD ID | ord-cbb21bec42474f60a019da7ee26d175a |
|---|
| 출처 메모 | uspto-grants-2006_06 |
|---|
