Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Potassium Phosphate, Tribasic → 2-(4-cyclopropylpyridin-3-yl)-3,4-dihydrobenzo[4,5]thieno[3,2-c]pyridin-1(2H)-one
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Potassium Phosphate, Tribasic | HCID 62657 | — |
| 반응물 | 3,4-Dihydro-[1]benzothieno[3,2-c]pyridin-1(2H)-one | HCID 20074905 | — |
| 반응물 | 4-Cyclopropyl-3-iodopyridine | HCID 66801887 | — |
| 촉매 | Copper iodide | HCID 83717 | — |
| 용매 | 1,4-Dioxane | HCID 31275 | — |
| 생성물 | 2-(4-cyclopropylpyridin-3-yl)-3,4-dihydrobenzo[4,5]thieno[3,2-c]pyridin-1(2H)-one | HCID 56941128 | 29.8% |
반응 단계
3,4-Dihydro-2H-benzo[4,5]thieno[3,2-c]pyridin-1-one (I-9d: 100 mg, 0.491 mmol) was reacted with 4-cyclopropyl-3-iodo-pyridine (I-73c: 133 mg, 0.65 mmol), 1,4-dioxane (3 mL), copper iodide (9.31 mg, 0.049 mmol), trans-N,N′-dimethyl-cyclohexyl-1,2-diamine (6.9 mg, 0.049 mmol) and potassium phosphate (313.3 mg, 1.47 mmol) to afford the crude product. Purification by column chromatography on silica gel (1% methanol in CHCl3) afforded 46.8 mg of the product (29.8% yield).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08946260B2 |
| 출처 데이터셋 | uspto-grants-2015_02 |
| ORD ID | ord-26eafa15bb9642e2b2d6b8584e44e57b |
| 출처 메모 | uspto-grants-2015_02 |