Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Hydrochloric Acid → 4-Amino-o-anisic acid
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | Lithium Hydroxide | HCID 3939 | — |
| 반응물 | Methyl 4-amino-o-anisate | HCID 168705 | — |
| 용매 | Oxolane--water (1/1) | HCID 21881883 | — |
| 생성물 | 4-Amino-o-anisic acid | HCID 75599 | 80% |
반응 단계
To a solution of 4-amino-2-methoxy benzoic acid methyl ester (5 g; 27 mmol) in THF/H2O (125 mL/25 mL) was added LiOH (4.8 g; 200 mmol) and the slurry was refluxed for 3.5 hours. The reaction mixture was neutralized using 4 M HCl (aq) and the resulting precipitate isolated by filtration and washed with H2O (2×15 mL) to give 3.26 g (80%) of an off-white solid. Mp. 144-146° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07741352B2 |
| 출처 데이터셋 | uspto-grants-2010_06 |
| ORD ID | ord-4a58bed4de92424b8104b6c9fd88edfc |
| 출처 메모 | uspto-grants-2010_06 |