Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2H-Pyran-3(4H)-one, dihydro- → 3-(3,4-Difluorophenyl)-1,4,5,7-tetrahydropyrano[3,4-c]pyrazole
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2H-Pyran-3(4H)-one, dihydro- | HCID 90109 | — |
| 반응물 | tert-butyl 3-(3,4-difluorophenyl)-6,7-dihydro-1H-pyrazolo[4,3-c]pyridine-5(4H)-carboxylate | HCID 59345327 | — |
| 생성물 | 3-(3,4-Difluorophenyl)-1,4,5,7-tetrahydropyrano[3,4-c]pyrazole | HCID 59345352 | — |
반응 단계
Intermediate 16B was prepared according to the procedure for the synthesis of intermediate 15 by replacing 1-Boc-4-piperidone with dihydro-2H-pyran-3(4H)-one LCMS (+ESI) m/z=236 [M+H]+. 1H NMR (CDCl3) δ 7.37-7.41 (m, 1H), 7.29-7.32 (m, 1H) 7.17-7.24 (m, 1H), 4.76 (s, 2H), 3.95 (t, J=5.5 Hz, 2H), 2.84 (t, J=5.5 Hz, 2H).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07741350B1 |
| 출처 데이터셋 | uspto-grants-2010_06 |
| ORD ID | ord-6e0b9274922e4fb6a2c5c20b9494402a |
| 출처 메모 | uspto-grants-2010_06 |