Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
1-(p-Tolyl)piperazine → 1-(7-Ethoxy-2,4,6-trimethyl-2,3-dihydro-1-benzofuran-5-yl)-4-(4-methylphenyl)piperazine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 1-(p-Tolyl)piperazine | HCID 83113 | — |
| 반응물 | HCID 66759168 | HCID 66759168 | — |
| 생성물 | 1-(7-Ethoxy-2,4,6-trimethyl-2,3-dihydro-1-benzofuran-5-yl)-4-(4-methylphenyl)piperazine | HCID 59485045 | 43% |
반응 단계
By using 5-bromo-7-ethoxy-2,4,6-trimethyl-2,3-dihydro-1-benzofuran (570 mg, 2.0 mmol) synthesized in Reference example 84 and 1-(4-methylphenyl)piperazine (704 mg, 4.0 mmol), the reaction was carried out in the same manner as Example 21 to synthesize the title compound 327 mg (yield 43%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08957069B2 |
| 출처 데이터셋 | uspto-grants-2015_02 |
| ORD ID | ord-5169d4738da04a5d94fb7c7ac228ba09 |
| 출처 메모 | uspto-grants-2015_02 |