Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
1-(p-Tolyl)piperazine → {2,4,6,7-Tetramethyl-5-[4-(4-methylphenyl)piperazin-1-yl]-2,3-dihydro-1-benzofuran-2-yl}methanol
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 1-(p-Tolyl)piperazine | HCID 83113 | — |
| 반응물 | (5-Bromo-2,4,6,7-tetramethyl-2,3-dihydro-1-benzofuran-2-yl)methanol | HCID 66759014 | — |
| 생성물 | {2,4,6,7-Tetramethyl-5-[4-(4-methylphenyl)piperazin-1-yl]-2,3-dihydro-1-benzofuran-2-yl}methanol | HCID 59485073 | 6.8% |
반응 단계
By using (5-bromo-2,4,6,7-tetramethyl-2,3-dihydro-1-benzofuran-2-yl)methanol (360 mg, 1.16 mmol) synthesized in Reference example 123 and 1-(4-methylphenyl)piperazine (668 mg, 3.79 mmol), the reaction was carried out in the same manner as Example 1 to obtain the title compound 30 mg (yield 6%). Melting point was 152 to 155° C. (ethyl acetate-hexane).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08957069B2 |
| 출처 데이터셋 | uspto-grants-2015_02 |
| ORD ID | ord-a260bc2b189b47a4b67355c91a2acaf0 |
| 출처 메모 | uspto-grants-2015_02 |