Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2-Propylpiperidine → 4-(2-Propyl-piperidin-1-yl)-butyronitrile
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2-Propylpiperidine | HCID 9985 | — |
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | 4-Bromobutyronitrile | HCID 21412 | — |
| 반응물 | Dichloromethane methanol | HCID 21226129 | — |
| 용매 | Acetonitrile | HCID 6342 | — |
| 용매 | Sodium chloride; water | HCID 57417360 | — |
| 생성물 | 4-(2-Propyl-piperidin-1-yl)-butyronitrile | HCID 18626322 | 83% |
반응 단계
A mixture of 2-propylpiperidine (550 mg, 4.3 mmol), 4-bromobutyronitrile (430 mg, 3.0 mmol) and potassium carbonate (550 mg, 4.0 mmol) in acetonitrile (5 mL) was stirred at rt for 12 h., followed by addition of a saturated brine (25 mL). The reaction mixture was extracted with ethyl acetate (3×25 mL) and the combined organic phases were dried (MgSO4) and evaporated to dryness to produce crude 8. The crude product was subjected to CC [eluent: CH2Cl2: MeOH (99: 1)] to give pure 8 (0.48 g, 83%); LC-MS [M+H]+194 (cald. 194.2).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06528529B1 |
| 출처 데이터셋 | uspto-grants-2003_03 |
| ORD ID | ord-b0ad0b4a84f843378a0a9731812c0337 |
| 출처 메모 | uspto-grants-2003_03 |