Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Methanol → 5-Amino-1,2-dihydroquinolin-2-one
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Methanol | HCID 887 | — |
| 반응물 | 5-Nitro-1,2-dihydroquinolin-2-one | HCID 243776 | — |
| 반응물 | HCID 178418361 | HCID 178418361 | — |
| 촉매 | Palladium | HCID 23938 | — |
| 용매 | Ethyl Acetate | HCID 8857 | — |
| 생성물 | 5-Amino-1,2-dihydroquinolin-2-one | HCID 15719078 | 100.3% |
반응 단계
4.5 g of 5-nitroquinolin-2(1H)-one (Chem. Pharm. Bull. (1981), 29, pp. 651-56) is hydrogenated in 200 ml of ethyl acetate and 500 ml of methanol in the presence of 450 mg of palladium on activated carbon as a catalyst under normal pressure with hydrogen until the reaction is completed. The catalyst is removed by filtration through diatomaceous earth, and the reaction solution is concentrated by evaporation in a vacuum. 3.8 g of the title compound is obtained as a yellow solid.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07638515B2 |
| 출처 데이터셋 | uspto-grants-2009_12 |
| ORD ID | ord-75c3d875ab254ea4a461d78a402bba6f |
| 출처 메모 | uspto-grants-2009_12 |