Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Hydrochloric Acid → 1-[2-Fluoro-3-(trifluoromethyl)phenyl]-4-propylpiperazine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | 1-Iodopropane | HCID 33643 | — |
| 반응물 | 1-(2-Fluoro-3-(trifluoromethyl)phenyl)piperazine | HCID 57448041 | — |
| 용매 | Acetonitrile | HCID 6342 | — |
| 생성물 | 1-[2-Fluoro-3-(trifluoromethyl)phenyl]-4-propylpiperazine | HCID 11601723 | — |
반응 단계
Preparation according to Example 1: 1-[2-fluoro-3-(trifluoro-methyl)phenyl]piperazine (0.97 g, 3.9 mmol), acetonitrile (50 ml), potassium carbonate (0.81 g, 5.86 mmol) and 1-iodopropane (0.457 ml, 4.6 mmol). Yield: 0.57 g (50%). The amine was converted to the hydrochloric acid salt and recrystallized from ethanol/diethyl ether: M.p. 180-181° C. MS m/z (relative intensity, 70 eV) 290 (M+, 22), 262 (13), 261 (bp), 218 (18), 190 (22).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08314126B2 |
| 출처 데이터셋 | uspto-grants-2012_11 |
| ORD ID | ord-0d284d251f1f4b198a4e197d6e8eb448 |
| 출처 메모 | uspto-grants-2012_11 |