Piperidine → HCID 23369884, 화합물

HRID 1898935

반응식

HRID 1898935 반응식
[OH:1][C:2]1[C:3]([C:13]([O:15][CH2:16][CH3:17])=[O:14])=[CH:4][C:5]2[C:10]([CH:11]=1)=[C:9]([OH:12])[CH:8]=[CH:7][CH:6]=2.[N+:18]([C:21]1[CH:22]=[C:23]([CH:32]=[CH:33][CH:34]=1)[CH:24]=[C:25]([C:30]#[N:31])[CH:26](O)C#N)([O-:20])=[O:19].[NH:35]1CCCCC1>C(O)C.CCOCC>[NH2:31][C:30]1[O:12][C:9]2[C:10]3[C:5]([CH:6]=[CH:7][C:8]=2[CH:24]([C:23]2[CH:32]=[CH:33][CH:34]=[C:21]([N+:18]([O-:20])=[O:19])[CH:22]=2)[C:25]=1[C:26]#[N:35])=[CH:4][C:3]([C:13]([O:15][CH2:16][CH3:17])=[O:14])=[C:2]([OH:1])[CH:11]=3

참가 물질

6

반응물 3

HCID 8082PiperidineHCID 14773083Ethyl 3,5-dihydroxynaphthalene-2-carboxylateHCID 53825579HCID 53825579, 화합물

생성물 1

HCID 23369884HCID 23369884, 화합물

시약·촉매·용매 2

HCID 702Ethanol용매HCID 3283Diethyl Ether용매

실험 절차

To a solution of ethyl 3,5-dihydroxynaphthalene-2-carboxylate (4.5 g) in ethanol (40 ml) was added 3-nitrobenzylidenemalonitrile (3.9 g) and piperidine (1.95 ml). The mixture was heated under reflux for 15 minutes whereupon a yellow precipitate was observed to form. The mixture was allowed to cool to room temperature, diluted with ether (100 ml) and the solid filtered off to yield ethyl 2-amino-3-cyano-9-hydroxy-4-(3-nitrophenyl)-4H -naphtho[1,2-b]pyran-8-carboxylate as a yellow powder, m.p. 260°-261° C. (dec.)

후처리

  1. temperatureThe mixture was heated
  2. temperatureunder reflux for 15 minutes whereupon a yellow precipitate
  3. customto form
  4. filtrationthe solid filtered off

출처 및 근거

ORD 기록
ord-62e348a3c14447a6a7e9d31071cc2d75
출처 데이터셋
uspto-grants-1996_11
특허 번호
US05571818

연결된 노트

불러오는 중…