Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Toluene → (E)-ethyl 3-(5-hydroxy-[1,1'-biphenyl]-2-yl)acrylate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Toluene | HCID 1140 | — |
| 반응물 | Carboxymethylene triphenylphosphorane | HCID 10870911 | — |
| 반응물 | 5-Hydroxy-[1,1'-biphenyl]-2-carbaldehyde | HCID 57303464 | — |
| 생성물 | (E)-ethyl 3-(5-hydroxy-[1,1'-biphenyl]-2-yl)acrylate | HCID 58566652 | — |
반응 단계
A solution of 5-hydroxy-[1,1′-biphenyl]-2-carbaldehyde (651) (292 mg, 1.47 mmol) and (carboxymethylene)-triphenylphosphorane (564.5 mg, 1.62 mmol) in toluene (15 mL) was refluxed for 24 hours. The reaction was concentrated in vacuo and was purified by flash column chromatography on silica gel with hexanes and EtOAc (30%) to give (E)-ethyl 3-(5-hydroxy-[1,1′-biphenyl]-2-yl)acrylate (652).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08598374B2 |
| 출처 데이터셋 | uspto-grants-2013_12 |
| ORD ID | ord-fbe773790a124d9987d1933f8f5716e3 |
| 출처 메모 | uspto-grants-2013_12 |