Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 1916539생성일: 2026년 10월 24일
2,4-Dichlorophenylboric acid → 5-(2,4-Dichloro-phenyl)-2-[4-(4-pyrrolidin-1-ylmethyl-phenyl)-but-1-ynyl]-pyridine
https://huagongshe.com/ko/reaction/1916539
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | 2,4-Dichlorophenylboric acid | HCID 21984477 | — |
| 반응물 | 5-Bromo-2-[4-(4-pyrrolidin-1-ylmethyl-phenyl)-but-1-ynyl]-pyridine | HCID 69071391 | — |
| 용매 | Sodium Carbonate | HCID 10340 | — |
| 용매 | 1,4-Dioxane | HCID 31275 | — |
| 생성물 | 5-(2,4-Dichloro-phenyl)-2-[4-(4-pyrrolidin-1-ylmethyl-phenyl)-but-1-ynyl]-pyridine | HCID 11743679 | — |
반응 단계
10 mg (0.01 mmol) tetrakis-triphenylphosphane-palladium are added to a suspension of 60 mg (0.16 mmol) 5-bromo-2-[4-(4-pyrrolidin-1-ylmethyl-phenyl)-but-1-ynyl]-pyridine and 63 mg (0.32 mmol) 2,4-dichlorophenylboric acid in 4 mL 1,4-dioxane and 1 mL 2 M Na2CO3 solution and the reaction mixture is stirred for 1 h at 110° C. The mixture is evaporated down i. vac. and the residue is extracted twice with in each case 15 mL EtOH. The solvent is removed and the residue is purified by HPLC.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US08618132B2 |
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| 출처 데이터셋 | uspto-grants-2013_12 |
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| ORD ID | ord-ce43bbbb8e494ce2b06988513ee96b05 |
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| 출처 메모 | uspto-grants-2013_12 |
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