Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Methyl 1-((acetylthio)methyl)cyclopropaneacetate → Montelukast
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Methyl 1-((acetylthio)methyl)cyclopropaneacetate | HCID 53482060 | — |
| 반응물 | HCID 54063535 | HCID 54063535 | — |
| 용매 | Acetonitrile | HCID 6342 | — |
| 용매 | Hydrazine | HCID 9321 | — |
| 용매 | Cesium carbonate | HCID 10796 | — |
| 용매 | Pyran | HCID 186148 | — |
| 생성물 | Montelukast | HCID 5281040 | — |
반응 단계
The process for the preparation comprises of reacting 2-(2-(2-(3(S)-(3-(2-(7-chloro-2-quinolinyl)ethenyl)phenyl)-3-(methanesulfonyloxy)propyl)phenyl)-2-propoxy)tetrahydro pyran with Methyl 1-(acetylthiomethyl)cyclopropane acetate in presence of hydrazine, cesium carbonate in acetonitrile as solvent to get methyl ester of Montelukast in pyran protected form. The protected compound is further reacted with pyridinium p-toluene sulfonate, sodium hydroxide in a mixture of methanol and tetrahydrofuran as a solvent to afford Montelukast sodium of Formula (I).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08178680B2 |
| 출처 데이터셋 | uspto-grants-2012_05 |
| ORD ID | ord-914a322d1f0848398bc757714fa30e17 |
| 출처 메모 | uspto-grants-2012_05 |