참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Formic Acid | HCID 284 | — |
| 반응물 | Ethylamine | HCID 6341 | — |
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | Acetylacetone | HCID 31261 | — |
| 반응물 | 5-Methyl hydrogen L-glutamate | HCID 68662 | — |
| 용매 | Methanol | HCID 887 | — |
| 용매 | Isopropanol | HCID 3776 | — |
| 생성물 | L-Theanine | HCID 439378 | 82% |
반응 단계
First, 20.0 g (0.124 mol) of L-glutamic acid-γ-methyl ester was suspended in 20 g of methanol. To this, 13.7 g (0.137 mol) of acetylacetone and 12.5 g (0.124 mol) of triethylamine were added. The mixture was stirred at 60° C. for one hour. Subsequently, 80 g (1.24 mol) of 70% ethylamine was added to the mixture. After the mixture was allowed to react for 6 hours, excessive ethylamine was distilled away under reduced pressure. To this, 11.4 g (0.246 mol) of formic acid and 120 mL of 2-propanol (IPA) were added. The crystal precipitated was filtrated by suction and washed with 20 mL of IPA to obtain wet matter. The wet matter was dried under reduced pressure to obtain 17.7 g of theanine as a white crystal substance (yield: 82%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US08178722B2 |
|---|
| 출처 데이터셋 | uspto-grants-2012_05 |
|---|
| ORD ID | ord-a804b629c46443cbad14b550f62e952b |
|---|
| 출처 메모 | uspto-grants-2012_05 |
|---|
