Bromine → 2-bromo-1-(3-nitrophenyl)propan-1-one

HRID 1942990

반응식

HRID 1942990 반응식
[N+:1]([C:4]1[CH:5]=[C:6]([C:10](=[O:13])[CH2:11][CH3:12])[CH:7]=[CH:8][CH:9]=1)([O-:3])=[O:2].[Br:14]Br>C(O)(=O)C>[Br:14][CH:11]([CH3:12])[C:10]([C:6]1[CH:7]=[CH:8][CH:9]=[C:4]([N+:1]([O-:3])=[O:2])[CH:5]=1)=[O:13]

참가 물질

4

반응물 2

HCID 24408BromineHCID 870963'-Nitropropiophenone

생성물 1

HCID 102644672-bromo-1-(3-nitrophenyl)propan-1-one

시약·촉매·용매 1

HCID 176Acetic Acid용매

실험 절차

To a stirred solution of 1-(3-nitrophenyl)propan-1-one (1.41 g, 7.90 mmol) in acetic acid (20 mL) was added bromine dropwise (1.27 g, 7.93 mmol) and the mixture was stirred at room temperature for 24 h. The mixture was poured into ice-cold water and the organic layer was extracted with DCM. The organic extract was washed with sat. aq. NaHCO3 and brine, dried over anhydrous MgSO4, and filtered. Evaporation of the solvent under reduced pressure afforded 11z as a white solid which was used in the next step without further purification (1.78 g, 87%). 1H NMR matches literature data.

후처리

  1. additionThe mixture was poured into ice-cold water
  2. extractionthe organic layer was extracted with DCM
  3. extractionThe organic extract
  4. washwas washed with sat. aq. NaHCO3 and brine
  5. dry with materialdried over anhydrous MgSO4
  6. filtrationfiltered
  7. customEvaporation of the solvent under reduced pressure

출처 및 근거

ORD 기록
ord-244e704eab064c4daa8d3aa73bb770ea
출처 데이터셋
uspto-grants-2013_03
특허 번호
US08389736B2

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