Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Hydrochloric Acid → 4-(p-Iodophenyl)butyric acid
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | Potassium Iodide | HCID 4875 | — |
| 반응물 | 4-(4-Aminophenyl)butanoic acid | HCID 27049 | — |
| 반응물 | Sodium Nitrite | HCID 23668193 | — |
| 생성물 | 4-(p-Iodophenyl)butyric acid | HCID 4645427 | — |
반응 단계
A 5 C mixture of 4-(4-aminophenyl)butyric acid (1.0 eq) and aqueous 6N hydrochloric acid (5.44 eq) was treated with 1.05 eq of a 3N aqueous solution of sodium nitrite, adding slowly so as to keep the temperature below 5 C. A solution of 2.8N aqueous potassium iodide (1.01 eq) was added. The reaction was stirred overnight. The layers were separated. The organic phase was purified by flash chromatography using methanol/methylene chloride as eluant to give 4-(4-iodophenyl)butyric acid.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07744910B2 |
| 출처 데이터셋 | uspto-grants-2010_06 |
| ORD ID | ord-b1722475e6454080a4154f9c9988b203 |
| 출처 메모 | uspto-grants-2010_06 |