Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 19608생성일: 2026년 10월 23일
tert-Butyl (4-aminophenyl)carbamate → {4-[5-(6-Benzyloxy-naphthalen-2-yl)-pyrazolo[1,5-c]pyrimidin-7-ylamino]-phenyl}-carbamic acid tert-butyl ester
https://huagongshe.com/ko/reaction/19608
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | tert-Butyl (4-aminophenyl)carbamate | HCID 688611 | — |
| 반응물 | 5-(6-Benzyloxy-naphthalen-2-yl)-7-methanesulfonyl-pyrazolo[1,5-c]pyrimidine | HCID 67319776 | — |
| 생성물 | {4-[5-(6-Benzyloxy-naphthalen-2-yl)-pyrazolo[1,5-c]pyrimidin-7-ylamino]-phenyl}-carbamic acid tert-butyl ester | HCID 67319245 | 46% |
반응 단계
A mixture of 5-(6-benzyloxy-naphthalen-2-yl)-7-methanesulfonyl-pyrazolo[1,5-c]pyrimidine (compound D2)(87 mg) and 4-amino-phenyl-carbamic acid tert-butyl ester (208 mg) is heated neat at 130 to 140° C. bath temperature for 20 min. After cooling, the crude product is purified by silica gel flash chromatography. A nearly colorless solid (51 mg, 46%) with melting temperature of 189° C. is obtained.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US07745446B2 |
|---|
| 출처 데이터셋 | uspto-grants-2010_06 |
|---|
| ORD ID | ord-511010926b6f4983a5ba276bd9effa2d |
|---|
| 출처 메모 | uspto-grants-2010_06 |
|---|
