Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Triethylamine → N-(4,5-Diphenyl-thiazol-2-yl)-4-methyl-benzamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | 4-Methylbenzoyl Chloride | HCID 13405 | — |
| 반응물 | 2-Amino-4,5-diphenylthiazole | HCID 73222 | — |
| 용매 | 1,4-Dioxane | HCID 31275 | — |
| 생성물 | N-(4,5-Diphenyl-thiazol-2-yl)-4-methyl-benzamide | HCID 3112499 | — |
반응 단계
4,5-Diphenyl-thiazol-2-ylamine (50.5 mg, 0.200 mmol) and 4-methyl-benzoyl chloride (30.9 mg, 0.200 mmol) were dissolved in 1,4-dioxane (2 mL) containing triethylamine (84.1 μL, 0.600 mmol). The reaction mixture was subjected to microwave irradiation for 5 minutes at 200° C. The crude product was filtered, evaporated to dryness, dissolved in 1 mL of dimethylsulfoxide and purified by reverse-phase preparative liquid chromatography (18.6 mg, 0.0502 mmol, 25.1%). ESI-MS m/z calc. 370.1. found 371.2 (M+1)+ Retention time 4.13 minutes.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08431605B2 |
| 출처 데이터셋 | uspto-grants-2013_04 |
| ORD ID | ord-65539746e06a4513b54776ed34bbf8ff |
| 출처 메모 | uspto-grants-2013_04 |