HCID 36845230, 화합물 → N-methyl-2-piperazin-1-ylacetamide

HRID 1972727

반응식

HRID 1972727 반응식
C([N:8]1[CH2:13][CH2:12][N:11]([CH2:14][C:15]([NH:17][CH3:18])=[O:16])[CH2:10][CH2:9]1)C1C=CC=CC=1>[Pd].CCO>[CH3:18][NH:17][C:15](=[O:16])[CH2:14][N:11]1[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]1

참가 물질

4

반응물 1

HCID 36845230HCID 36845230, 화합물

생성물 1

HCID 4962075N-methyl-2-piperazin-1-ylacetamide수율 98.9%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 702Ethanol용매2회

실험 절차

10% Palladium on carbon (115 mg, 10% by wt.) was placed under an inert atmosphere and suspended in EtOH (5 mL). A solution of 2-(4-benzyl-piperazin-1-yl)-N-methyl-acetamide (1.15 g, 4.65 mmol) dissolved in EtOH (18 mL) was added. The reaction mixture was placed under H2 atmosphere (1 Atm pressure) and stirred overnight. The resulting mixture was filtered through a pad of Celite® and the solvent was concentrated in vacuo to give 723 mg (98.9%) of the title compound as a white solid. 1H-NMR (300 MHz, DMSO-d6) 7.61 (broad s, 1H), 2.80 (s, 2H), 2.68 (t, 4H), 2.59 (d, 3H), 2.31 to 2.26 (m, 4H); ES-MS m/z 158.0 [M+H]+, RT (min) 1.13.

후처리

  1. additionwas added
  2. filtrationThe resulting mixture was filtered through a pad of Celite®
  3. concentrationthe solvent was concentrated in vacuo

출처 및 근거

ORD 기록
ord-831faa8a6f864fac96be13c9251261ac
출처 데이터셋
uspto-grants-2013_04
특허 번호
US08431695B2

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