Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Trifluoroacetic acid → 2-(4-{3-[1-(3,4-Dimethyl-benzyl)-2-oxo-imidazolidin-4-yl]-propyl]-phenoxy}-2-methyl-propionic acid
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Trifluoroacetic acid | HCID 6422 | — |
| 반응물 | 2-(4-{3-[1-(3,4-Dimethyl-benzyl)-2-oxo-imidazolidin-4-yl]-propyl}-phenoxy)-2-methyl-propionic acid tert-butyl ester | HCID 57718897 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | 2-(4-{3-[1-(3,4-Dimethyl-benzyl)-2-oxo-imidazolidin-4-yl]-propyl]-phenoxy}-2-methyl-propionic acid | HCID 57718900 | 24.4% |
반응 단계
A solution of 2-(4-{3-[1-(3,4-dimethyl-benzyl)-2-oxo-imidazolidin-4-yl]-propyl}-phenoxy)-2-methyl-propionic acid tert-butyl ester (0.051 g, 0.106 mmol) in CH2Cl2 (3 mL) was treated with trifluoroacetic acid (0.5 mL) and stirred at room temperature under N2 for 5 h. The solvent removed in vacuo to give crude acid that was purified by flash chromatography using 94:6 CH2Cl2:MeOH to afford 0.011 g (24%) 2-(4-{3-[1-(3,4-dimethyl-benzyl)-2-oxo-imidazolidin-4-yl]-propyl}-phenoxy) -2-methyl-propionic acid. MS (ES+) Calc'd for C25H33N2O4 (M+1) 425. Found m/z 425 (100%). 1H NMR.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07544812B2 |
| 출처 데이터셋 | uspto-grants-2009_06 |
| ORD ID | ord-63854d25743f4357b5361d6f95f13c17 |
| 출처 메모 | uspto-grants-2009_06 |