Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Ammonia → 2-Amino-2-iminoethylcarbamate AcOH
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Ammonia | HCID 222 | — |
| 반응물 | N-Acetyl-L-Cysteine | HCID 12035 | — |
| 반응물 | tert-butyl N-(cyanomethyl)carbamate | HCID 545844 | — |
| 용매 | Methanol | HCID 887 | — |
| 생성물 | 2-Amino-2-iminoethylcarbamate AcOH | HCID 131727841 | 62.6% |
반응 단계
N-Boc-aminoacetonitrile (40.2 g, 257.4 mmol) and N-acetylcysteine (42.0 g, 257.4 mmol) were dissolved in methanol (300 mL) at 60° C. and ammonia was passed through for 18 h. The solvent was removed in vacuo. After ion exchange chromatography (Amberlite IRA-400 (AcOH)) and recrystallisation from acetone, 28.4 g (53%) of the sub-title compound was obtained as a white solid.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07645751B2 |
| 출처 데이터셋 | uspto-grants-2010_01 |
| ORD ID | ord-7cb4b35b7c9f42a59a85e231a3293f05 |
| 출처 메모 | uspto-grants-2010_01 |