Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2,4-Dichlorothiazole → (S)-methyl 2-(tert-butoxycarbonyl)-3-(4-chlorothiazol-2-yl)propanoate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2,4-Dichlorothiazole | HCID 12333155 | — |
| 반응물 | (R)-methyl2-(tert-butoxycarbonyl)-3-iodopropanoate | HCID 86614124 | — |
| 생성물 | (S)-methyl 2-(tert-butoxycarbonyl)-3-(4-chlorothiazol-2-yl)propanoate | HCID 67305732 | — |
반응 단계
The title compound was synthesized in a manner analogous to that described Example 475, using (R)-methyl 2-(tert-butoxycarbonyl)-3-iodopropanoate and 2,4-dichlorothiazole (prepared according to Reynaud, Pierre; Robba, Max; Moreau, Robert C; New synthesis of the thiazole ring; Bulletin de la Societe Chimique de France (1962), 1735-8). MS m/z: 321 (23%, M+1), 265.0 (100%, M−55.1).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07745484B2 |
| 출처 데이터셋 | uspto-grants-2010_06 |
| ORD ID | ord-64d1d7ba6333472782ac0a3b90a1e555 |
| 출처 메모 | uspto-grants-2010_06 |