참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | Diethyl isopropylidenemalonate | HCID 81255 | — |
| 반응물 | HCID 178490607 | HCID 178490607 | — |
| 용매 | Diethyl Ether | HCID 3283 | — |
| 생성물 | Diethyl 2-(1-(4-methoxyphenyl)-2-methylpropan-2-yl)malonate | HCID 67304572 | — |
반응 단계
Diethylisopropylidenemalonate (6.686 ml, 34.09 mmol) was dissolved in 300 ml Et2O and cooled to −78° C. 4-Methoxybenzylmagnesium chloride (150.000 ml, 37.50 mmol) was added and stirring was continued for 5 h. The temperature was warmed up to 0° C. The reaction was hydrolyzed with 0.5 M HCl and extracted 3×EtOAc. Glass col. Chromatography (10-50% EtOAc in Hex.) provided diethyl 2-(1-(4-methoxyphenyl)-2-methylpropan-2-yl)malonate. MS m/z: 323.1 (M+1).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US07745484B2 |
|---|
| 출처 데이터셋 | uspto-grants-2010_06 |
|---|
| ORD ID | ord-a116fb5593f14d639fa1ae35017a6363 |
|---|
| 출처 메모 | uspto-grants-2010_06 |
|---|
