Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Aluminium lithium hydride → 3-(Aminomethyl)-N-(2,4-dimethoxybenzyl)pyridin-2-amine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Aluminium lithium hydride | HCID 21226445 | — |
| 반응물 | 2-(2,4-Dimethoxybenzylamino)nicotinonitrile | HCID 22293175 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | 3-(Aminomethyl)-N-(2,4-dimethoxybenzyl)pyridin-2-amine | HCID 22293160 | 102.7% |
반응 단계
Lithium aluminum hydride (1.0 M in THF, 11.4 mL, 11.4 mmol) was added slowly to a solution of 2-[(2,4-dimethoxybenzyl)amino]nicotinonitrile (2.80 g, 10.4 mmol) in tetrahydrofuran (35 mL) at 0° C. The reaction was allowed to warm to room temperature and stir for 4 h. The reaction was carefully quenched with a saturated aqueous solution of sodium sulfate, filtered with copious dichloromethane and concentrated to produce the title compound (2.92 g). MS 274.3 (M+1).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07745427B2 |
| 출처 데이터셋 | uspto-grants-2010_06 |
| ORD ID | ord-f43c7d6f52ec4204a11e59a47f133434 |
| 출처 메모 | uspto-grants-2010_06 |