Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HCID 68563692, 화합물 → 5-(R)-[2-(S)-Amino-1-(S)-hydroxy-3-(3-hydroxyphenyl)-propyl]-2-(R)-(2,2-dimethylpropoxy)-3-(S)-methylmorpholine-4-carboxylic acid tert-butyl ester
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | HCID 68563692 | HCID 68563692 | — |
| 반응물 | HCID 178418361 | HCID 178418361 | — |
| 촉매 | Palladium hydroxide | HCID 9942167 | — |
| 용매 | tert-Butanol | HCID 6386 | — |
| 생성물 | 5-(R)-[2-(S)-Amino-1-(S)-hydroxy-3-(3-hydroxyphenyl)-propyl]-2-(R)-(2,2-dimethylpropoxy)-3-(S)-methylmorpholine-4-carboxylic acid tert-butyl ester | HCID 68561574 | 104.2% |
반응 단계
Dissolve 5-(R)-[1-(S)-benzyloxy-3-(3-benzyloxyphenyl)-2-(R)-dibenzylaminopropyl]-2-(R)-(2,2-dimethylpropoxy)-3-(S)-methylmorpholine-4-carboxylic acid tert-butyl ester (1.38 g, 1.70 mmol) in tert-butanol (˜50 mL). Add 20% palladium hydroxide on carbon (4 g) and hydrogenate at 50 psi hydrogen gas at 40° C. for 18 hours. Filter and concentrate to give the desired compound (802 mg).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07745438B2 |
| 출처 데이터셋 | uspto-grants-2010_06 |
| ORD ID | ord-f603027a811c4124b583d7961476ec7f |
| 출처 메모 | uspto-grants-2010_06 |