Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Triethylamine → (+-)-Trans-2-formyl-cyclopropanecarboxylic acid ethyl ester
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | Sulfur trioxide-pyridine | HCID 168533 | — |
| 반응물 | Ethyl (1R,2R)-2-(hydroxymethyl)cyclopropanecarboxylate | HCID 29920784 | — |
| 용매 | Dimethyl Sulfoxide | HCID 679 | — |
| 용매 | Diethyl Ether | HCID 3283 | — |
| 생성물 | (+-)-Trans-2-formyl-cyclopropanecarboxylic acid ethyl ester | HCID 7271792 | — |
반응 단계
Cool a solution of (+/−)-trans-2-hydroxymethyl-cyclopropanecarboxylic acid ethyl ester (0.22 g, 1.53 mmol) in 1.5 mL DMSO to 0° C. Add to the frozen solution triethyl-amine (0.85 mL, 0.62 mmol) followed by sulfur trioxide pyridine (0.49 g, 3.05 mmol). Warm reaction mixture to 12° C. over 3.5 hours, dilute with diethyl ether (80 mL), and wash with 5% aqueous citric acid (3×20 mL) followed by saturated aqueous sodium chloride (1×20 mL). Dry over magnesium sulfate and concentrate under reduced pressure to provide the desired compound.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07745438B2 |
| 출처 데이터셋 | uspto-grants-2010_06 |
| ORD ID | ord-37767759e28946f6af4b9007458d87cf |
| 출처 메모 | uspto-grants-2010_06 |