참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Formaldehyde | HCID 712 | — |
| 반응물 | Dimethylamine, hydrochloride | HCID 10473 | — |
| 반응물 | Sodium Hydroxide | HCID 14798 | — |
| 반응물 | 2,5-Dimethylpyrazine | HCID 31252 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | 2-(beta-Dimethylaminoethyl)-5-methylpyrazine | HCID 20377611 | 34.6% |
반응 단계
A mixture of 75.0 g (0.7 mole) of 2,5-dimethylpyrazine and 41.0 g (0.5 mole) of dimethylamine hydrochloride was heated at 140° C. 60.0 g (38% aqueous solution) (0.75 mole) of formaldehyde was added over a period of two hours. After two hours additional heating the mixture was cooled. It was diluted with 110 ml of water, made basic with 10% sodium hydroxide and extracted with chloroform. The solvent was removed and the residue distilled to give 28.6 g of 2-(β-dimethylaminoethyl)-5-methylpyrazine, b.p. 106°-110° C. at 10 mm Hg.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US04183933 |
|---|
| 출처 데이터셋 | uspto-grants-1980_01 |
|---|
| ORD ID | ord-8e7c5d9d62e44642ad0dfac211e1259f |
|---|
| 출처 메모 | uspto-grants-1980_01 |
|---|
