Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Triethylamine → 3,4-Difluoro-2-(2-fluoro-4-iodo-phenylamino)-N-(2-hydroxy-ethoxy)-5-(3-oxo-[1,4,2]dioxazinan-2-ylmethyl)-benzamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | Di(succinimido) carbonate | HCID 676246 | — |
| 반응물 | 3,4-difluoro-2-(2-fluoro-4-iodo-phenylamino)-N-(2-hydroxy-ethoxy)-5-[(2-hydroxy-ethoxyamino)-methyl]-benzamide | HCID 11577457 | — |
| 용매 | Tetrahydrofurane dichloromethane | HCID 21919333 | — |
| 생성물 | 3,4-Difluoro-2-(2-fluoro-4-iodo-phenylamino)-N-(2-hydroxy-ethoxy)-5-(3-oxo-[1,4,2]dioxazinan-2-ylmethyl)-benzamide | HCID 11613880 | 11.9% |
반응 단계
3,4-Difluoro-2-(2-fluoro-4-iodo-phenylamino)-N-(2-hydroxy-ethoxy)-5-[(2-hydroxy-ethoxyamino)-methyl]-benzamide (100 mg, 0.185 mmol) obtained in Example 6, N,N′-disuccinimidyl carbonate (59 mg, 0.231 mmol) and NEt3 (113 mg, 1.12 mmol) were stirred in a mixed solvent of CH2Cl2/THF (1 mL/1 mL) at room temperature for 10 hours. The reaction mixture was purified by silica gel column chromatography (CH2Cl2/MeOH as a developing solvent) to give the title compound (12.5 mg).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07745663B2 |
| 출처 데이터셋 | uspto-grants-2010_06 |
| ORD ID | ord-a04cc6577e8c435f82379ae55d30f143 |
| 출처 메모 | uspto-grants-2010_06 |