참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | Piperidin-4-ol | HCID 79341 | — |
| 반응물 | 1,2-Difluoro-4-nitrobenzene | HCID 123053 | — |
| 용매 | Chloroform | HCID 6212 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | 1-(2-Fluoro-4-nitrophenyl)piperidin-4-ol | HCID 26598221 | 43% |
반응 단계
To a solution of 4.77 g (30.0 mmol) of 3,4-difluoronitrobenzene in 100 mL of N,N-dimethylformamide were added 5.33 g (40.0 mmol) of potassium carbonate and 3.03 g (30.0 mmol) of 4-hydroxypiperidine and the mixture was stirred for 1 hour at 120° C. After the reaction mixture was cooled to room temperature, the reaction mixture was diluted with chloroform and insoluble substances were removed off by filtration. The filtrate was condensed and the residue was purified by silica gel column chromatography (eluent:hexane/ethyl acetate=1.5/1) to give 3.1 g (43%) of the title compound.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US07932250B2 |
|---|
| 출처 데이터셋 | uspto-grants-2011_04 |
|---|
| ORD ID | ord-23b85eafb65d4593aaae4190a3d37c85 |
|---|
| 출처 메모 | uspto-grants-2011_04 |
|---|
