Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Triethylamine → (+)-N-[{1-[bis(phenylmethyl)amino]cyclopentyl}(phenyl)methyl]-2,6-dimethylbenzamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | 2,6-Dimethylbenzoyl chloride | HCID 89096 | — |
| 반응물 | (+/-){1-[Amino(phenyl)methyl]cyclopentyl}bis(phenylmethyl)amine | HCID 59347885 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | (+)-N-[{1-[bis(phenylmethyl)amino]cyclopentyl}(phenyl)methyl]-2,6-dimethylbenzamide | HCID 59347832 | 80% |
반응 단계
The title compound (2.51 g; 80%) was prepared from (±)-{1-[amino(phenyl)methyl]cyclopentyl}bis(phenylmethyl)amine D33 (2.31 g; 6.23 mmol), 2,6-dimethyl benzoyl chloride (1.15 g; 6.85 mmol), triethylamine (1.73 ml; 12.5 mmol) in DCM (70 ml) in a similar manner to that described in E13. 1H NMR (CDCl3) δ: 1.40-2.05 (8H, m), 2.28 (6H, s), 3.68 (4H, s), 5.37 (1H, d), 6.78 (1H, m), 6.95-7.36 (16H, m), 7.45 (2H, m); Mass Spectrum (Electrospray LC/MS), API+: Found 503 (MH+). C35H38N2O requires 502. Ret. time 3.77 min.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07745642B2 |
| 출처 데이터셋 | uspto-grants-2010_06 |
| ORD ID | ord-3c32095997474e6aba7ea9903204b73c |
| 출처 메모 | uspto-grants-2010_06 |