Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Potassium Permanganate → 4-(Bis(benzyloxy)phosphoryloxy)benzoic acid
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Potassium Permanganate | HCID 516875 | — |
| 반응물 | Dichloromethane methanol | HCID 21226129 | — |
| 반응물 | Sodium Bisulfite | HCID 23665763 | — |
| 반응물 | Dibenzyl 4-formylphenyl phosphate | HCID 57798977 | — |
| 용매 | Acetone | HCID 180 | — |
| 용매 | Hydrochloric Acid | HCID 313 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | 4-(Bis(benzyloxy)phosphoryloxy)benzoic acid | HCID 18541117 | 90.1% |
반응 단계
To a solution of dibenzyl 4-formylphenyl phosphate (1.00 g, 2.62 mmol) in acetone (50 mL) was added a solution of potassium permanganate (0.837 g, 5.30 mmol) in acetone (40 mL) and water (40 mL) at rt over 1.5 hr. To the resulting purple mixture was poured 10% NaHSO3 in 1N HCl (100 mL) at rt. The purple solution became colorless and extracted with AcOEt (3×60 mL). The combined extract was washed with brine and dried anhydrous MgSO4. The title compound (0.940 g, 90% yield) was isolated as a white solid by ISCO (5% MeOH/CH2Cl2).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07572795B2 |
| 출처 데이터셋 | uspto-grants-2009_08 |
| ORD ID | ord-085d8233d79e480e87e7c8948c45fc50 |
| 출처 메모 | uspto-grants-2009_08 |