Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2-Aminopyridine-3-carboxamide → HCID 136127017, 화합물
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2-Aminopyridine-3-carboxamide | HCID 506623 | — |
| 반응물 | Lithium Hexamethyldisilazide | HCID 2733832 | — |
| 반응물 | (2-m-Tolyl-ethoxy)-acetic acid methyl ester | HCID 67099145 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | HCID 136127017 | HCID 136127017 | — |
반응 단계
In analogy to example 91.3, 2-amino-nicotinamide and (2-m-tolyl-ethoxy)-acetic acid methyl ester (prepared from 2-m-tolyl-ethanol [1875-89-4] in analogy to example 91.1-91.2) reacted in the presence of LiHMDS in THF to yield after purification of the crude product with column chromatography (silica gel, EtOAc) and crystallization from EtOAc/heptane 2-(2-m-tolyl-ethoxymethyl)-3H-pyrido[2,3-d]pyrimidin-4-one as white solid. MS (m/e): 296.4 [M+H+].
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07572801B2 |
| 출처 데이터셋 | uspto-grants-2009_08 |
| ORD ID | ord-a84520a329a5472bb330af52d0a1ca7b |
| 출처 메모 | uspto-grants-2009_08 |