참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Diisobutylamine | HCID 8085 | — |
| 반응물 | 1-Hydroxybenzotriazole | HCID 75771 | — |
| 반응물 | Diisopropylethylamine | HCID 81531 | — |
| 반응물 | [2-(2,2-Dimethylpropanoyl)-5-methoxy-1-benzofuran-3-yl]acetic acid | HCID 57804476 | — |
| 용매 | 1,2-Dichloroethane | HCID 11 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | 2-[2-(2,2-Dimethylpropanoyl)-5-methoxy-1-benzofuran-3-yl]-N,N-diisobutylacetamide | HCID 11350154 | — |
반응 단계
Dissolve a mixture of 17 mg [2-(2,2-dimethylpropanoyl)-5-methoxy-1-benzofuran-3-yl]acetic acid from the Step B Example 1 and 18.5 mg HOBt in 1 mL dry DMF. Add 15.4 μL di-i-butylamine followed by 23.0 mg EDC and 35 μL DIEA. This solution was heated at 40° C. for 2 hours. It was purified directly on RP-HPLC using 65-100% MeCN gradient. The fractions containing pure product were pooled and lyophilized to give the title compound. LC-MS: 4.42 min. (m/Z=318.2, 402.2, 424.2).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US07576122B2 |
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| 출처 데이터셋 | uspto-grants-2009_08 |
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| ORD ID | ord-85e94175ff08464a9636651522046be1 |
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| 출처 메모 | uspto-grants-2009_08 |
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